culturelle probiotic review

Culturelle is a probiotic brand that comes from the manufacturer i-Health, Inc. It is one of the well-reputed probiotic brands based on ingredients backed by solid science.

So what is Culturelle? Does it work? Let’s find out!


It is a symbiotic supplement, meaning that it contains a mixture of prebiotic and probiotic. It contains Lactobacillus GG, which is perhaps one of the most extensively researched probiotic strains. As for the prebiotic, it contains 200 mg inulin, which is a polysaccharide.

Price (4/5)

Culturelle comes in a box containing 30 vegan capsules, and costs $23.29. So the price per capsule is $0.77. The serving size is one capsule per day.

Average Rating (4/5)

It has a 4.2-star rating on Amazon based on 71 customer reviews, out of which 73% are 5-star, and 11% are 1-star.

On iHerb, its average score is 4.4-stars after 540 customer reviews. Out of these, 350 are 5-star reviews, followed by 88 4-stars, 48 3-stars, and 18 1-star reviews.

Side effects (4/5)

Most of the customers are happy with the results; but some have reported a range of side effects. The top side effects include:

  • Several customers have reported that they have not experienced any changes in their symptoms with the use of Culturelle.
  • Some say that they had to discontinue the product due to side effects like excessive gas and abdominal cramping.
  • Few customers have reported allergic reactions to the constituents of Culturelle.

CFU (5/5)

CFU stands for the colony forming units. According to research, for a product to be useful, the CFU in that product should be between 1 billion CFU up to 20 billion CFU (1). Culturelle contains 10 billion colony forming units, which is well within the required range.

Strains (4.5/5)

When it comes to the probiotic strain, most of the probiotics prefer ‘quantity over quality.’ Manufacturers argue that since human gut microbiome is a complex ecosystem, a single strain of probiotic is not enough to make for the probiotic deficiency. Also, if one probiotic strain does not work for someone, another strain might work just fine for him. This statement makes sense.

However, quantity is not always better than quality. Culturelle uses a single strain of probiotic. Still, it manages to get 4.5-stars in this category because it uses one of the most authentic and one of the most extensively researched probiotic strains known- Lactobacillus GG.

Here is what literature says about the efficacy of Lactobacillus GG.

Condition Role of Lactobacillus GG Research
Atopy and food allergies Probiotics, including Lactobacillus GG might be helpful in symptom resolution in atopic conditions in children including eczema, asthma, food allergies and so on. Roberto Berni Canani, et al., 2012
Antibiotic induced diarrhea in children Lactobacillus GG, when used in a dose of 10-20 billion CFU, can cause a significant reduction in antibiotic induced diarrhea. Bradley C Johnston, et al., 2005
Antibiotic induced diarrhea in adults Lactobacillus GG might also help improve symptoms in clostridium deficile diarrhea Mary Hickson, 2011
Crohn’s disease Lactobacillus GG might be helpful in inducing and maintain the remission of Crohn’s disease Schultz M et al., 2004
Treatment of infections Use of Lactobacillus helps improve rotavirus induced gastroenteritis Sugita T et al., 1994

Overall Rating 4.3/5

To sum up, Culturelle is a probiotic brand based on actual scientific evidence. It is helpful if you’re looking for something to uplift your digestive health. It might also be helpful in conditions like atopic disorders, diarrhea, infections and Crohn’s disease.


  1. BENJAMIN KLIGLER, ANDREAS COHRSSEN. Probiotics. Am Fam Physician. 2008 Nov 1; 78(9):1073-1078.
  2. Roberto Berni Canani, et al. The Potential Therapeutic Efficacy of Lactobacillus GG in Children with Food Allergies. Pharmaceuticals (Basel). 2012 Jun; 5(6): 655–664.
  3. Bradley C Johnston, et al. Does Lactobacillus GG prevent antibiotic-associated diarrhea in children? Paediatr Child Health. 2005 Mar; 10(3): 169–171.
  4. Schultz M et al. Lactobacillus GG in inducing and maintaining remission of Crohn’s disease. BMC Gastroenterol. 2004 Mar 15;4:5.
  5. Sugita T, Togawa M. Efficacy of Lactobacillus preparation Biolactis powder in children with rotavirus enteritis. Jpn J Pediatr. 1994;47:2755–2762